Epilepsy Ontario :: Medications :: Tiagabine Hydrochloride

Tiagabine Hydrochloride

Tiagabine is currently available in the United States, but not in Canada

Known as	Gabitril�
Uses	Effective against partial seizures (including secondary generalized tonic-clonic). Somewhat effective against primary generalized tonic-clonic. Ineffective against or may worsen absence, myoclonic, and tonic/atonic seizures. Good for patients refractory to other drugs. A therapeutic range for tiagabine levels in the blood has not yet been established. The safety and efficacy in children younger than 12 years of age has not been established.
How to Use	Take tiagabine as prescribed by your doctor. It should be taken with food. Loading dose = 4-8 mg/d, maintenance dose = 32-56 mg/d, bidaily or quarter-daily.
Side Effects	Reactions may include cramps, nausea, vomiting, weight loss, diarrhea, increased appetite, mouth ulcers, dizziness, drowsiness, general weakness, nervousness, tremors, difficulty concentrating, depression, hostility, sore throat and difficulty swallowing, cough, and skin rashes. Gastrointestinal upsets are decreased if taken with a meal.
Precautions	May generate new seizure types in patients with partial seizures. Do not stop taking tiagabine suddenly unless advised to do so by your doctor: you may have more frequent seizures. Do not drive or operate complex machinery until you have taken tiagabine long enough to gauge its effects on your mental and motor abilities. Because of possible additive effects, be careful if taking tiagabine with other central nervous system (CNS) depressants. People with impaired liver function or liver disease may need to take a lower dosage of tiagabine. During pregnancy, use tiagabine only if clearly needed. Tiagabine may be passed through breast milk. In laboratory tests, large doses of tiagabine have been implicated in birth defects in rats and rabbits and in the development of small cancers in the livers and testes of rats, and in structural chromosome aberrations.
Interactions	Tiagabine cases a slight decrease in valproate levels. Valproate may significantly increase the tiagabine concentration. Carbamazepine, phenobarbital and phenytoin may decrease the effect of tiagabine. Blood levels not changed by gabapentin, lamotrigine, topiramate, levetiracetam, oxcarbazepine, zonisamide. Effect of felbamate unknown.
Missed Dose	Take as soon as you remember; then resume medication schedule.
Storage	Store at room temperature, between 15�C and 30�C, away from children, heat, light and moisture.
Forms	Tablets

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